Issue 16, 2023

Nickel-catalyzed reductive coupling of arylcarboxylic acid 2-pyridyl esters with alkyl methanesulfonates: access to alkyl aryl ketones

Abstract

Alkyl aryl ketones were synthesized via a nickel-catalyzed reductive coupling reaction of arylcarboxylic acid (2-pyridyl)esters with primary and secondary alkyl methanesulfonates under mild reaction conditions. This method suits a wide range of substrates and shows good compatibility with functional groups.

Graphical abstract: Nickel-catalyzed reductive coupling of arylcarboxylic acid 2-pyridyl esters with alkyl methanesulfonates: access to alkyl aryl ketones

Supplementary files

Article information

Article type
Paper
Submitted
23 Feb 2023
Accepted
30 Mar 2023
First published
30 Mar 2023

Org. Biomol. Chem., 2023,21, 3423-3431

Nickel-catalyzed reductive coupling of arylcarboxylic acid 2-pyridyl esters with alkyl methanesulfonates: access to alkyl aryl ketones

H. Yu and Z. Wang, Org. Biomol. Chem., 2023, 21, 3423 DOI: 10.1039/D3OB00293D

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