Issue 13, 2023

Photocatalytic synthesis of alkyl–alkyl sulfones via direct C(sp3)–H bond functionalization

Abstract

We report a highly efficient one-pot, three-component strategy for the construction of alkyl–alkyl sulfones through a photoinduced TBADT-catalyzed C(sp3)–H sulfonylation of unactivated hydrocarbon compounds. A wide range of commercially available hydrocarbon compounds and bioactive molecules can be successfully applied to the catalytic system, affording the corresponding alkyl–alkyl sulfones in good to excellent yields (>50 examples, up to 87% yield).

Graphical abstract: Photocatalytic synthesis of alkyl–alkyl sulfones via direct C(sp3)–H bond functionalization

Supplementary files

Article information

Article type
Paper
Submitted
21 Feb 2023
Accepted
10 Mar 2023
First published
16 Mar 2023

Org. Biomol. Chem., 2023,21, 2822-2827

Photocatalytic synthesis of alkyl–alkyl sulfones via direct C(sp3)–H bond functionalization

W. Lu, D. Yang, G. Wang, T. Wang, Y. Zhou and L. Jing, Org. Biomol. Chem., 2023, 21, 2822 DOI: 10.1039/D3OB00276D

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