A convergent procedure for the formal synthesis of cyclotheonellazole A in high yields and excellent stereoselectivity has been developed. This synthesis features an efficient preparation of O-pivaloyl-protected α-hydroxy-β-amino amides and a one-pot process to introduce the challenging thiazole moiety. The overall synthesis is very efficient and paves the way for the preparation of analogues for drug development.
B. Long, L. Pu, Z. Liu, X. Zeng and Z. Wu, Org. Biomol. Chem., 2023, 21, 3531 DOI: 10.1039/D3OB00038A
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