Issue 5, 2023
From the journal:

Organic & Biomolecular Chemistry

Towards the use of an amino acid cleavable linker for solid-phase chemical synthesis of peptides and proteins†

Davide Cardella, ORCID logo a   Yu-Hsuan Tsai ORCID logo *b  and  Louis Y. P. Luk ORCID logo *a  

* Corresponding authors

a School of Chemistry, Cardiff University, Cardiff CF10 3AT, UK
E-mail: lukly@cardiff.ac.uk

b Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen 518132, China
E-mail: tsai.y-h@outlook.com

Abstract

The synthesis of proteins by solid-phase chemical ligation (SPCL) suffers from the paucity of linkers that can be cleaved under mild conditions. Here, we deployed a spontaneous nickel-assisted cleavage (SNAC) tag, known to undergo spontaneous cleavage in the presence of nickel(II), as a linker for C-to-N SPCL.

Graphical abstract: Towards the use of an amino acid cleavable linker for solid-phase chemical synthesis of peptides and proteins

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D2OB02198F
Article type
Communication
Submitted
02 Dec 2022
Accepted
22 Dec 2022
First published
23 Dec 2022
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2023,21, 966-969

Permissions

Request permissions

Towards the use of an amino acid cleavable linker for solid-phase chemical synthesis of peptides and proteins

D. Cardella, Y. Tsai and L. Y. P. Luk, Org. Biomol. Chem., 2023, 21, 966 DOI: 10.1039/D2OB02198F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements