Issue 1, 2023

Enantio- and diastereoselective boron conjugate addition to α-alkyl α,β-unsaturated esters

Abstract

We developed a copper-catalyzed enantio- and diastereoselective boron conjugate addition to α-alkyl α,β-unsaturated esters under base-free conditions. The approach showed excellent enantioselectivities (87–99% ee) and moderate to good conversions (51–99%), albeit with moderate diastereoselectivities (1 : 1–17 : 1 dr). The synthetic utility of this protocol was demonstrated.

Graphical abstract: Enantio- and diastereoselective boron conjugate addition to α-alkyl α,β-unsaturated esters

Supplementary files

Article information

Article type
Communication
Submitted
21 Oct 2022
Accepted
24 Nov 2022
First published
25 Nov 2022

Org. Biomol. Chem., 2023,21, 53-58

Enantio- and diastereoselective boron conjugate addition to α-alkyl α,β-unsaturated esters

M. Li, G. Peng, X. Yang, Z. Ma and J. Xie, Org. Biomol. Chem., 2023, 21, 53 DOI: 10.1039/D2OB01928K

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