Issue 45, 2023

Small extracellular vesicles administered directly in the brain promote neuroprotection and decreased microglia reactivity in a stroke mouse model

Abstract

Herein, we investigate the bioactivity of small extracellular vesicles (sEVs), focusing on their local effect in the brain. sEVs from mononuclear cells (MNCs) showed superior effects in vitro to sEVs from mesenchymal stem cells (MSCs) and were able to promote neuroprotection and decrease microglia reactivity in a stroke mouse model.

Graphical abstract: Small extracellular vesicles administered directly in the brain promote neuroprotection and decreased microglia reactivity in a stroke mouse model

Supplementary files

Article information

Article type
Communication
Submitted
02 Aug 2023
Accepted
24 Oct 2023
First published
07 Nov 2023
This article is Open Access
Creative Commons BY license

Nanoscale, 2023,15, 18212-18217

Small extracellular vesicles administered directly in the brain promote neuroprotection and decreased microglia reactivity in a stroke mouse model

M. M. Lino, T. Rondão, A. Banerjee, I. Aires, M. Rodrigues, T. Reis, A. Santinha, D. Fernandes, D. Serrenho, T. Sobrino, J. Sargento-Freitas, F. C. Pereira, A. L. Carvalho and L. Ferreira, Nanoscale, 2023, 15, 18212 DOI: 10.1039/D3NR03861K

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