Issue 34, 2023

Mimicking the extracellular matrix by incorporating functionalized graphene into hybrid hydrogels

Abstract

The efficient functionalization of graphene with sulfonic groups using a sustainable approach facilitates the interaction of biomolecules with its surface. The inclusion of these graphene sheets inside a photopolymerized acrylamide-based hydrogel provides a 3D scaffold with viscoelastic behaviour closer to that found in natural tissues. Cell-culture experiments and differentiation assays with SH-SY5Y cells showed that these hybrid hydrogels are non-cytotoxic, thus making them potentially useful as scaffold materials mimicking the extracellular environment.

Graphical abstract: Mimicking the extracellular matrix by incorporating functionalized graphene into hybrid hydrogels

Supplementary files

Article information

Article type
Paper
Submitted
07 Jun 2023
Accepted
31 Jul 2023
First published
21 Aug 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2023,15, 14238-14248

Mimicking the extracellular matrix by incorporating functionalized graphene into hybrid hydrogels

J. M. Galindo, I. San-Millán, C. A. Castillo-Sarmiento, I. Ballesteros-Yáñez, M. A. Herrero, S. Merino and E. Vázquez, Nanoscale, 2023, 15, 14238 DOI: 10.1039/D3NR02689B

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