Issue 33, 2023

Ultrasound meets the cell membrane: for enhanced endocytosis and drug delivery

Abstract

Endocytosis plays a crucial role in drug delivery for precision therapy. As a non-invasive and spatiotemporal-controllable stimulus, ultrasound (US) has been utilized for improving drug delivery efficiency due to its ability to enhance cell membrane permeability. When US meets the cell membrane, the well-known cavitation effect generated by US can cause various biophysical effects, facilitating the delivery of various cargoes, especially nanocarriers. The comprehension of recent progress in the biophysical mechanism governing the interaction between ultrasound and cell membranes holds significant implications for the broader scientific community, particularly in drug delivery and nanomedicine. This review will summarize the latest research results on the biological effects and mechanisms of US-enhanced cellular endocytosis. Moreover, the latest achievements in US-related biomedical applications will be discussed. Finally, challenges and opportunities of US-enhanced endocytosis for biomedical applications will be provided.

Graphical abstract: Ultrasound meets the cell membrane: for enhanced endocytosis and drug delivery

Article information

Article type
Minireview
Submitted
31 May 2023
Accepted
14 Jul 2023
First published
19 Jul 2023

Nanoscale, 2023,15, 13532-13545

Ultrasound meets the cell membrane: for enhanced endocytosis and drug delivery

Z. Wen, C. Liu, Z. Teng, Q. Jin, Z. Liao, X. Zhu and S. Huo, Nanoscale, 2023, 15, 13532 DOI: 10.1039/D3NR02562D

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