Issue 14, 2023

Rh single-atom nanozymes for efficient ascorbic acid oxidation and detection

Abstract

The management of ascorbic acid (AA) in biological fluids is of significant importance for body functions and human health, yet challenging due to the lack of high-performance sensing catalysts. Herein, we report the design of Rh single-atom nanozymes (Rh SAzymes) by mimicking the active sites of ascorbate peroxidase toward efficient electrocatalytic oxidation and detection of AA. Benefiting from the enzyme-mimicking single-atom coordination, the Rh SAzyme exhibits an unprecedented electrocatalytic activity for AA oxidation with an onset potential as low as 0.02 V (vs. Ag/AgCl). Combined with the screen-printing technology, a miniaturized Rh SAzyme biosensor was firstly constructed for tracking dynamic trends of AA in the human subject and detecting AA content in nutritional products. The as-prepared biosensor exhibits excellent detection performances with a wide linear range of 10.0 μM–53.1 mM, a low detection limit of 0.26 μM, and a long stability of 28 days. This work opens a door for the design of artificial single-atom electrocatalysts to mimic natural enzymes and their subsequent application in biosensors.

Graphical abstract: Rh single-atom nanozymes for efficient ascorbic acid oxidation and detection

Supplementary files

Article information

Article type
Paper
Submitted
02 Feb 2023
Accepted
11 Mar 2023
First published
13 Mar 2023

Nanoscale, 2023,15, 6629-6635

Rh single-atom nanozymes for efficient ascorbic acid oxidation and detection

X. Shi, J. Li, Y. Xiong, Z. Liu, J. Zhan and B. Cai, Nanoscale, 2023, 15, 6629 DOI: 10.1039/D3NR00488K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements