Issue 45, 2023

Modulating the antibacterial activity of a CuO@HKUST-1 nanocomposite by optimizing its synthesis procedure

Abstract

The loading and encapsulating of functional antibacterial agents on the surface or into the well-ordered pores of metal–organic frameworks (MOFs) effectively decreases their aggregation, leading to their increased contact with bacteria, thus enhancing the antibacterial performance. In this study, HKUST-1 was investigated to investigate the antibacterial activity of MOFs that have metal oxides in their pores (CuO@HKUST-1). HKUST-1 was synthesized via a solvothermal reaction and [Cu(CH3COO)2·H2O]0.47@HKUST-1 was synthesized through the immersion of HKUST-1 in an aqueous solution of Cu(CH3COO)2·H2O. Then, two [CuO]0.87@HKUST-1 and [CuO]0.65@HKUST-1 nanocomposites were prepared via the thermal treatment of HKUST-1 and [Cu(CH3COO)2·H2O]0.47@HKUST-1 at 295 °C and 290 °C under a N2 atmosphere, respectively. FT-IR, PXRD, TGA, ICP-OES, FE-SEM and EDS mapping analyses proved the successful synthesis of these compounds. Finally, the antibacterial activity of the nanocomposites was investigated against Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria.

Graphical abstract: Modulating the antibacterial activity of a CuO@HKUST-1 nanocomposite by optimizing its synthesis procedure

Supplementary files

Article information

Article type
Paper
Submitted
21 Aug 2023
Accepted
16 Oct 2023
First published
31 Oct 2023

New J. Chem., 2023,47, 20770-20776

Modulating the antibacterial activity of a CuO@HKUST-1 nanocomposite by optimizing its synthesis procedure

A. Arshadi Edlo and K. Akhbari, New J. Chem., 2023, 47, 20770 DOI: 10.1039/D3NJ03914E

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