Issue 32, 2023

A facile synthesis of CuZrO2 nanoparticle functionalized chitosan for capable and stable non-enzymatic electrochemical detection of glucose and H2O2

Abstract

Mixed transition metal oxides and organic polymers are receiving a lot of interest because of their positive characteristics, such as high permeability, large specific surface area, and ion dispersion paths. In this work, CuZrO2 and CuZrO2 anchored chitosan (CS) nanoparticles were fabricated and characterized by FT-IR, micro-Raman, XPS, P-XRD, EIS, HR-SEM, HR-TEM, AFM and TGA. It was found that the CuZrO2 NPs were successfully decorated and well dispersed on the surface of CS without agglomeration. When compared to bare GCE and CuZrO2–GCE, the proposed CuZrO2–CS nanoparticles demonstrated superior electrochemical features and sensing capabilities for glucose and H2O2 detection. The sensing ability of the fabricated electrodes was examined, the CuZrO2/CS electrode demonstrated high sensing ability (3.801 μA mM−1 cm−2) with a quick reaction time (4 s), a low limit of detection (LOD) (2.02 μM), and selectivity when compared to CuZrO2. Furthermore, the electrode exhibited outstanding H2O2 detection with a fast reaction time of 3 s, a wide linearity from 5 μM to 6.840 mM, a high-level sensitivity of 8.22 μA mM−1 cm−2 and a LOD of 2.03 μM. We also examined the practicability of CuZrO2–CS NPs for the sensing of glucose and H2O2 in real-time samples of blood serum and active cancer HeLa cells. We expect that this research work can provide a new understanding of nanocomposites to realize a simple and reliable electrochemical glucose and H2O2 sensing system.

Graphical abstract: A facile synthesis of CuZrO2 nanoparticle functionalized chitosan for capable and stable non-enzymatic electrochemical detection of glucose and H2O2

Supplementary files

Article information

Article type
Paper
Submitted
12 May 2023
Accepted
17 Jul 2023
First published
17 Jul 2023

New J. Chem., 2023,47, 15099-15110

A facile synthesis of CuZrO2 nanoparticle functionalized chitosan for capable and stable non-enzymatic electrochemical detection of glucose and H2O2

R. Madhaiyan, S. Chinnusamy, U. Seeman and J. Ramasamy, New J. Chem., 2023, 47, 15099 DOI: 10.1039/D3NJ02177G

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