Issue 21, 2023

Highly diastereoselective Heck–Matsuda reaction with pyrazolyl diazonium salts

Abstract

The Heck–Matsuda (HM) reaction is a powerful synthetic approach cut out for C–C bonds formation under mild conditions. We demonstrated that pyrazolyl diazonium salts are suitable reagents in this protocol, allowing us to deliver highly substituted cyclopentenols and cyclopentenamines with an excellent degree of diastereoselectivity and a control of enantioselectivity.

Graphical abstract: Highly diastereoselective Heck–Matsuda reaction with pyrazolyl diazonium salts

Supplementary files

Article information

Article type
Communication
Submitted
18 Apr 2023
Accepted
05 May 2023
First published
18 May 2023
This article is Open Access
Creative Commons BY-NC license

New J. Chem., 2023,47, 9994-9997

Highly diastereoselective Heck–Matsuda reaction with pyrazolyl diazonium salts

F. Bellina, F. Berti, S. M. Bertozzi, T. Bandiera and F. Bertozzi, New J. Chem., 2023, 47, 9994 DOI: 10.1039/D3NJ01724A

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