Copper-promoted indirect trifluoromethylthiolation of sulfuryl chloride with TMSCF3: facile access to trifluoromethyl thioethers

Changge Zheng; Kui Zhao; Chao Jiang; Ruilong Feng; Chunxiang Li; Xifei Chen; Chongbin Wei; Xinxin Gong; Jianquan Hong

doi:10.1039/D3NJ01319G

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Copper-promoted indirect trifluoromethylthiolation of sulfuryl chloride with TMSCF₃: facile access to trifluoromethyl thioethers†

Changge Zheng,

*^a Kui Zhao,^a Chao Jiang,^a Ruilong Feng,^a Chunxiang Li,^a Xifei Chen,^a Chongbin Wei,^a Xinxin Gong^a and Jianquan Hong*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China
E-mail: cgzheng@jiangnan.edu.cn

Abstract

A simple and practical synthetic method for trifluoromethyl thioethers through copper-promoted indirect trifluoromethylthiolation has been developed. The reaction of sulfuryl chloride with commercial Ruppert–Prakash reagent TMSCF3 is performed under mild reaction conditions. This transformation efficiently affords various aryl or alkyl sulfuryl trifluoromethyl thioethers with mild reaction conditions, wide substrate scope and excellent compatibility.

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Article information

DOI: https://doi.org/10.1039/D3NJ01319G
Article type: Paper
Submitted: 20 Mar 2023
Accepted: 20 Jun 2023
First published: 21 Jun 2023

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New J. Chem., 2023,47, 13671-13675

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Copper-promoted indirect trifluoromethylthiolation of sulfuryl chloride with TMSCF₃: facile access to trifluoromethyl thioethers

C. Zheng, K. Zhao, C. Jiang, R. Feng, C. Li, X. Chen, C. Wei, X. Gong and J. Hong, New J. Chem., 2023, 47, 13671 DOI: 10.1039/D3NJ01319G

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