2-Aminofluorene based triazole cocktailed with organosilane as UV-visible and fluorescence sensor for the highly selective detection of Fe(iii) ion and its anti-leishmanial activity

Abstract

In this study, we have developed 2-aminofluorene-based triazole-attached novel organosilanes with click chemistry approach, and the newly synthesized compounds are comprehensively studied using NMR (¹H and ¹³C) spectroscopy, TGA, and mass spectrometry. Further, using UV-visible and fluorescence spectroscopy, the sensing behavior of probe 6a was found to be highly selective for Fe(III) ion over other tested metal ions, with LOD values of 0.0723 × 10⁻⁸ M and 0.5825 × 10⁻⁹ M, which are significantly lower than WHO drinking water guidelines. The DFT investigations have furnished essential aspects concerning the interaction of the compound with the Fe(III) metal ion. The ¹H NMR and XPS studies of 6a and 6a + Fe³⁺ have confirmed the mode of the binding of 6a with Fe(III). Leishmaniasis is a contagious, neglected tropical disease with complex treatment therapy. Therefore, developing a new pharmaceutical that can act as an inhibitory agent for this illness may be a useful tactic to speed up the drug discovery process. In view of this, in vitro and molecular docking investigations into the inhibitory effects of probe 6a on the leishmaniasis protein were done, and both produced positive results.