PhI(OAc)2-mediated C–N bond cleavage of acylhydrazines with amines for the synthesis of amides

Shun Yang; Haiying Tian; Ling Li; Ying Wang; Cong Xie; Xiuling Chen

doi:10.1039/D2NJ05938J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

PhI(OAc)₂-mediated C–N bond cleavage of acylhydrazines with amines for the synthesis of amides†

Shun Yang,‡^a Haiying Tian,‡^b Ling Li,^a Ying Wang,^a Cong Xie*^a and Xiuling Chen

*^a

Author affiliations

* Corresponding authors

^a School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437100, China
E-mail: cxl828800@163.com
Fax: +86-715-8338007

^b Department of Pharmacy, Changzhi Medical College, Changzhi 046000, P. R. China

Abstract

Amides are an important class of compounds in pharmaceutical and agrochemical chemistry. Herein, we report a novel procedure for the synthesis of amides via PhI(OAc)₂-mediated C–N bond cleavage of acylhydrazines with amines under metal free conditions. The protocol shows broad substrate scope, high yields, and simple and mild operation.

Download options Please wait...

Supplementary files

Supplementary information PDF (3028K)

Article information

DOI: https://doi.org/10.1039/D2NJ05938J
Article type: Communication
Submitted: 03 Dec 2022
Accepted: 09 Jan 2023
First published: 10 Jan 2023

Download Citation

New J. Chem., 2023,47, 3663-3667

Permissions

Request permissions

PhI(OAc)₂-mediated C–N bond cleavage of acylhydrazines with amines for the synthesis of amides

S. Yang, H. Tian, L. Li, Y. Wang, C. Xie and X. Chen, New J. Chem., 2023, 47, 3663 DOI: 10.1039/D2NJ05938J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

New Journal of Chemistry