NaHBEt3-catalyzed HBpin hydroboration and deoxygenation of primary, secondary, and tertiary amides

Abstract

The reduction of amides to amines has always been a challenging yet attractive process. Herein, we show that in the presence of NaHBEt₃ acting as a catalyst, primary, secondary and tertiary amides can be reduced by HBpin, with a wide range of substrates and functional group tolerance. A plausible experimental mechanism is proposed based on control experimental reactions.