Issue 1, 2023

A novel delivery vehicle for copper peptides

Abstract

While glycyl-L-histidyl-L-lysine-copper (GHK-Cu) has a variety of biological functions, it is not easily absorbed by skin directly, which along with several contraindications, greatly limit its clinical use. We developed an ionic-liquid-based delivery vehicle composed of betaine and tartaric acid to address the difficulties associated with the use of GHK-Cu. The prepared ionic liquid is safe, stable, and able to deliver a high GHK-Cu drug-loading capacity while maintaining the activity of GHK-Cu and ensuring its biological functions. In addition, it substantially improves the permeability of GHK-Cu to deeper skin layers. The ionic-liquid delivery vehicle, which was developed by combining experimental and theoretical studies, provides a simple, low-cost, and effective method for applying GHK-Cu while providing design ideas for active peptides in general.

Graphical abstract: A novel delivery vehicle for copper peptides

Supplementary files

Article information

Article type
Paper
Submitted
28 Aug 2022
Accepted
13 Nov 2022
First published
24 Nov 2022

New J. Chem., 2023,47, 75-83

A novel delivery vehicle for copper peptides

T. Liu, L. Hu, B. Lu, Y. Bo, Y. Liao, J. Zhan, Y. Pei, H. Sun, Z. Wang, C. Guo and J. Zhang, New J. Chem., 2023, 47, 75 DOI: 10.1039/D2NJ04282G

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