Simple engineering of hybrid cellulose nanocrystal–gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties

Giacomo Biagiotti; Gianluca Toniolo; Martin Albino; Mirko Severi; Patrizia Andreozzi; Marcello Marelli; Hana Kokot; Giancarlo Tria; Annalisa Guerri; Claudio Sangregorio; Javier Rojo; Debora Berti; Marco Marradi; Stefano Cicchi; Iztok Urbančič; Yvette van Kooyk; Fabrizio Chiodo; Barbara Richichi

doi:10.1039/D3NH00063J

Simple engineering of hybrid cellulose nanocrystal–gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties†

Giacomo Biagiotti,‡^a Gianluca Toniolo,‡^ab Martin Albino,

^ac Mirko Severi,

^a Patrizia Andreozzi,^a Marcello Marelli,^d Hana Kokot,^e Giancarlo Tria,^a Annalisa Guerri,

^a Claudio Sangregorio,^c Javier Rojo,

^f Debora Berti,

^ag Marco Marradi,

^a Stefano Cicchi,

^ab Iztok Urbančič,^e Yvette van Kooyk,^h Fabrizio Chiodo

*^hi and Barbara Richichi

*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry “Ugo Schiff”, University of Firenze, Via della Lastruccia 13, 50019 Sesto Fiorentino (Firenze), Italy
E-mail: barbara.richichi@unifi.it

^b Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), 50121 Firenze, Italy

^c ICCOM CNR via Madonna del Piano 10, 50019 Sesto Fiorentino (Firenze), Italy

^d Istituto di Scienze e Tecnologie Chimiche “Giulio Natta”, SCITEC-CNR, Via G. Fantoli 16/15, Milano, Italy

^e Laboratory of Biophysics, Condensed Matter Physics Department, Jožef Stefan Institute, Jamova c. 39, Ljubljana, Slovenia

^f Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Av. Américo Vespucio 49, Seville, Spain

^g Italian Center for Colloid and Surface Science (CSGI), 50019 Sesto Fiorentino (Firenze), Italy

^h Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Amsterdam Infection and Immunity Institute, Amsterdam, The Netherlands
E-mail: f.chiodo@amsterdamumc.nl

ⁱ Institute of Biomolecular Chemistry, National Research Council (CNR), Pozzuoli, Napoli, Italy

Abstract

Cellulose nanocrystal and gold nanoparticles are assembled, in a unique way, to yield a novel modular glyconanomaterial whose surface is then easily engineered with one or two different headgroups, by exploiting a robust click chemistry route. We demonstrate the potential of this approach by conjugating monosaccharide headgroups to the glyconanomaterial and show that the sugars retain their binding capability to C-type lectin receptors, as also directly visualized by cryo-TEM.

This article is part of the themed collections: Celebrating International Women’s day 2024: Women in Nanoscience and Nanoscale and Nanoscale Horizons: Nanoparticle Synthesis

Nanoscale Horizons

Simple engineering of hybrid cellulose nanocrystal–gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Simple engineering of hybrid cellulose nanocrystal–gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties

Social activity

Search articles by author

Spotlight

Advertisements