Issue 18, 2023

A biocompatible NIR-II light-responsive nanoknife for permanent male sterilization

Abstract

Nanomaterial-mediated photothermal therapy (PTT) is a promising strategy for permanent male sterilization owing to its easy operation, rapid heating, minimal invasiveness, and high spatiotemporal controllability. However, the currently available PTT for male sterilization utilizes irradiation sources in the first near-infrared window (NIR-I), which may suffer from incomplete sterilization due to the insufficient penetration depth of NIR-I light. Herein, we developed a facile one-pot hydrothermal synthetic method of cysteine-coated copper sulfide (Cys-CuS) nanosheets for the second NIR window (NIR-II) PTT-mediated permanent male sterilization. In this method, Cys acted not only as a template but also as a sulfur resource in the formation of Cys-CuS nanosheets. The obtained Cys-CuS nanosheets possessed good photothermal properties and satisfied deep-tissue light response capacity under 1064 nm laser exposure. Given this, the permanent male sterilization in vivo was readily achieved by Cys-CuS nanosheets in a rapid manner (only 40 s). To the best of our knowledge, it is the first time that nanomaterial-mediated NIR-II PTT is applied for permanent male sterilization. We believe that the facilely prepared biocompatible Cys-CuS nanosheets can serve as a promising NIR-II light-responsive nanoknife to control the overpopulation of domestic pets and stray animals.

Graphical abstract: A biocompatible NIR-II light-responsive nanoknife for permanent male sterilization

Supplementary files

Article information

Article type
Paper
Submitted
26 Mar 2023
Accepted
08 Aug 2023
First published
16 Aug 2023
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2023,5, 5029-5035

A biocompatible NIR-II light-responsive nanoknife for permanent male sterilization

H. Wang, X. Yue, H. Wu, Y. Wan, Y. Tong, Y. Zhao, Y. Li and J. Pan, Nanoscale Adv., 2023, 5, 5029 DOI: 10.1039/D3NA00189J

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