Cu2O/Co3O4 nanoarrays for rapid quantitative analysis of hydrogen sulfide in blood

Abstract

2D heterostructure nanoarrays have emerged as a promising sensing material for rapid disease detection applications. In this study, a bio-H₂S sensor based on Cu₂O/Co₃O₄ nanoarrays was proposed, the controllable preparation of the nanoarrays being achieved by exploring the experimental parameters of the 2D electrodeposition in situ assembly process. The nanoarrays were designed as a multi-barrier system with strict periodicity and long-range order. Based on the interfacial conductance modulation and vulcanization reaction of Cu₂O and Co₃O₄, the sensor exhibited superior sensitivity, selectivity, and stability to H₂S in human blood. In addition, the sensor exhibited a reasonable response to 0.1 μmol L⁻¹ Na₂S solution, indicating that it had a low detection limit for practical applications. Moreover, first-principles calculations were performed to study changes in the heterointerface during the sensing process and the mechanism of rapid response of the sensor. This work demonstrated the reliability of Cu₂O/Co₃O₄ nanoarrays applied in portable sensors for the rapid detection of bio-H₂S.