Issue 5, 2023

Learning from human metabolism for nanomedicine: a convertible bismuth-agent for tumour-selective theranostics

Abstract

Tumour-selective theranostic agents have attracted considerable interest over the past decade in oncology owing to their extraordinary anticancer efficacy. However, it still remains a challenge to develop theranostic agents balancing biocompatibility, multidimensional theranostics, tumour-selectivity, and simple components. Inspired by the metabolic pathways of exogenous sodium selenite against selenium-deficient diseases, reported here is the first convertible bismuth-based agent for tumour-selective theranostic functionalities. The specifically overexpressed substances in tumour tissue enable it to act as a natural reactor for the conversion from bismuth selenite to bismuth selenide, activating the theranostic functionalities specifically in tumour tissues. The converted product exhibits excellent multidimensional imaging-guided therapy. This study not only demonstrates a simple agent with both biocompatibility and sophisticated tumour-selective theranostic functionalities, but also pioneers a new approach from emulating nature towards oncological theranostic applications.

Graphical abstract: Learning from human metabolism for nanomedicine: a convertible bismuth-agent for tumour-selective theranostics

Supplementary files

Article information

Article type
Communication
Submitted
18 Jan 2023
Accepted
24 Feb 2023
First published
27 Feb 2023

Mater. Horiz., 2023,10, 1835-1841

Learning from human metabolism for nanomedicine: a convertible bismuth-agent for tumour-selective theranostics

Q. Cao, C. Yang, Y. Yao, B. Li, J. Liu, Z. Cao, J. Liu and M. Xiao, Mater. Horiz., 2023, 10, 1835 DOI: 10.1039/D3MH00077J

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