En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies

Marie Belhajová; Aleš Vícha; Ladislav Burgert; Iveta Brožková; Ludmila Michalíčková; Radim Hrdina; Tomáš Moravec; David Netuka; Zdeněk Musil; Radim Hrdina

doi:10.1039/D3MD00261F

En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies

Marie Belhajová,^a Aleš Vícha,^a Ladislav Burgert,^b Iveta Brožková,^b Ludmila Michalíčková,^b Radim Hrdina,

^b Tomáš Moravec,^c David Netuka,^c Zdeněk Musil*^d and Radim Hrdina

*^e

Author affiliations

* Corresponding authors

^a Charles University, Faculty of Medicine, Department of paediatric haematology and oncology, V Úvalu 84/1, 150 00 Praha 5, Czech Republic

^b University of Pardubice, Faculty of Chemical Technology, Studentská 573, 53210 Pardubice, Czech Republic

^c Charles University, Faculty of Medicine, Department of neurosurgery and neurooncology, U Vojenské nemocnice, 1200 Praha 6, Czech Republic

^d Charles University, Faculty of Medicine, Institute of biology and medical genetics, Albertov 4, Praha 2, Czech Republic
E-mail: zdenek.musil@lf1.cuni.cz

^e Charles University, Faculty of Science, Department of Organic Chemistry, Hlavova 8, 12843 Praha 2, Czech Republic
E-mail: hrdina@natur.cuni.cz

Abstract

We report the preparation, characterisation and in vitro tests of hyaluronan fibres containing up to 50 w/w% of temozolomide for local glyoblastoma treatment. These fibres form a hydrogel upon contact with cerebrospinal fluid on the treatment spot.

RSC Medicinal Chemistry

En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies

Abstract

Article information

Download Citation

Permissions

En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies

Social activity

Search articles by author

Spotlight

Advertisements