Issue 6, 2023
From the journal:

RSC Medicinal Chemistry

Novel pirfenidone derivatives: synthesis and biological evaluation†

Maoling Yao, ORCID logo a   Maoru Sun,a   Congdi Chen,b   Liming Jin,c   Hongjun Yang,*a   Yong Li*d  and  Shufan Yine  

* Corresponding authors

a Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University, Chengdu 610041, China
E-mail: yanghj@swun.edu.cn

b College of Chemistry and Life Science, Chengdu Normal University, Chengdu 611130, China

c Key Laboratory of Biotechnology and Bioresources Utilization, Ministry of Education, Dalian Minzu University, Dalian 116600, China

d Innovation Center of Nursing Research, Nursing Key Laboratoryof Sichuan Province, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, China
E-mail: liyong562@126.com

e College of Chemistry, Sichuan University, Chengdu, China

Abstract

In order to discover novel anti-pulmonary fibrosis agents, a series of novel pirfenidone derivatives were designed and synthesized. All compounds were investigated for their anti-pulmonary activity and characterized by 13C and 1H nuclear magnetic resonance and high-resolution mass spectrometry. Preliminary studies on their biological activity showed that all target compounds showed different degrees of inhibition on pulmonary fibrosis, and most of the derivatives were significantly better than pirfenidone.

Graphical abstract: Novel pirfenidone derivatives: synthesis and biological evaluation

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Article information

DOI
https://doi.org/10.1039/D3MD00072A
Article type
Research Article
Submitted
16 Feb 2023
Accepted
25 Apr 2023
First published
19 May 2023

RSC Med. Chem., 2023,14, 1158-1164

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Novel pirfenidone derivatives: synthesis and biological evaluation

M. Yao, M. Sun, C. Chen, L. Jin, H. Yang, Y. Li and S. Yin, RSC Med. Chem., 2023, 14, 1158 DOI: 10.1039/D3MD00072A

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