Issue 17, 2023

Water-soluble ferrous metallacage combined with oxaliplatin for a synergistic chemo/chemodynamic therapy

Abstract

We designed and synthesized a nanoplatform for chemotherapy (CT) combined with enhanced chemodynamic therapy (CDT). A self-assembly of FM@OXA-PEG was formed by a water-soluble and amphipathic ferrous metallacage (FM), hydrophilic copolymer (PEG2000-COOH) and oxaliplatin (OXA). The FM proved to be an excellent Fenton reaction catalyst and a potential CDT agent. OXA can not only act as an anti-tumor drug but also activate intracellular nicotinamide adenine dinucleotide phosphate oxidase (NOX) and superoxide dismutase (SOD) to produce H2O2, enhancing the CDT effect and realizing synergistic CT and CDT. In vitro and in vivo experimental results showed that FM@OXA-PEG had almost no toxicity to normal cells but had obvious killing capacity for tumor cells and significantly inhibited the growth of tumors.

Graphical abstract: Water-soluble ferrous metallacage combined with oxaliplatin for a synergistic chemo/chemodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
24 May 2023
Accepted
27 Jul 2023
First published
31 Jul 2023
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2023,4, 3813-3821

Water-soluble ferrous metallacage combined with oxaliplatin for a synergistic chemo/chemodynamic therapy

J. He, W. He, R. Wang, J. Jiao and S. Yang, Mater. Adv., 2023, 4, 3813 DOI: 10.1039/D3MA00264K

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