Issue 14, 2023

Scalable production of microscopic particles for biological delivery

Abstract

Microscopic particles (nano- and micro-particles) have shown great potential as biological delivery carriers, with notable success stories such as in DOXIL and COVID-19 vaccines. Translation of these advanced drug delivery systems to industry/clinic is challenging, with scalable production being one of the keys. This review summarizes efforts in the literature in developing scalable production processes for microscopic particle-based bio-delivery systems. These scalable production processes include both batch processes and continuous processes such as microfluidics, flash technology, and electrospray. The materials used for particle-based delivery carriers include organic, inorganic, as well as hybrid materials. Finally, we also discuss the downstream processes after production, e.g., purification, bioconjugation, sterilization, and storage.

Graphical abstract: Scalable production of microscopic particles for biological delivery

Article information

Article type
Review Article
Submitted
12 Jan 2023
Accepted
12 Jun 2023
First published
16 Jun 2023
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2023,4, 2885-2908

Scalable production of microscopic particles for biological delivery

H. Lin, J. Leng, P. Fan, Z. Xu and G. Ruan, Mater. Adv., 2023, 4, 2885 DOI: 10.1039/D3MA00021D

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