Diastereoselective organophotocatalytic hydrosulfonylation of cyclopropenes

Abstract

Herein, we present a remarkably efficient, highly diastereoselective organophotoredox-catalyzed hydrosulfonylation of cyclopropenes. This method employs sodium sulfinates to successfully construct poly-substituted sulfonated cyclopropane derivatives. To enhance the applicability of this transformation, we demonstrate its broad applicability across a wide range of substrates, its scalability for large-scale synthesis, and its compatibility with late-stage functionalization. Notably, this late-stage functionalization protocol exhibits good tolerance toward diverse functional groups. Its operational convenience further adds to its appeal, providing access to valuable building blocks that hold great significance in drug discovery and medicinal chemistry.