Photo/electrocatalytic site-selective C–H functionalization of 8-aminoquinolines and their analogues

Abstract

8-Aminoquinolines and their analogues are important nitrogenous compounds that are widely used in organic chemistry, medicinal chemistry, material science and other fields. In recent years, the synthesis of functional 8-aminoquinolines and their analogues has become a research hotspot for organic and pharmaceutical chemists, and great progress has been made. Photo/electrochemistry-induced C–H functionalization provides a new concept for modern synthetic chemistry, which is greener, more atom- and step-economic. Therefore, as a green and efficient synthetic strategy, photo/electrocatalysis can be used for the selective C–H functionalization of 8-aminoquinolines and their analogues. In this study, 8-aminoquinoline, 8-hydroxyquinoline, and 1-naphthylamine scaffolds are classified, and the constructions of their selective C–H activation systems are reviewed in terms of photocatalytic and electrocatalytic synthesis. Finally, an outlook for the future of this field is summerized.