Additive-free aerobic oxidative difunctionalization of alkenes with P4S10 and alcohols to access β-hydroxy phosphorodithioates

Abstract

An efficient strategy has been exploited for the synthesis of β-hydroxy phosphorodithioates via additive-free aerobic oxidative difunctionalization of alkenes with P₄S₁₀ and alcohols at room temperature. This transformation provides a facile approach to access a series of β-hydroxy phosphorodithioates in moderate to good yields by using eco-friendly air (O₂) as the sole oxidant and oxygen source. Notably, the hydrophosphorodithiolation products could be efficiently and selectively obtained when 2-vinylpyridine and α,β-unsaturated carbonyl compounds were utilized in this reaction system.