Metal-free, visible-light driven α-C(sp3)–H gem-difluoroallylation of glycine derivatives with trifluoromethyl alkenes and 1,3-enynes

Abstract

A metal free, visible-light driven α-C(sp³)–H gem-difluoroallylation of glycine derivatives with trifluoromethyl alkenes and 1,3-enynes is presented. This protocol features mild and redox-neutral conditions, broad substrate scope, excellent functional group compatibility, as well as high atom-efficiency, thus offering a sustainable and practical strategy to access fluorine-containing unnatural amino acids and peptides. The good scalability and excellent compatibility with biomolecules further highlight the potential utility of this protocol.