Electrochemical enabled cascaded cyclization of enaminones with thiocyanate and alcohols access to 2-alkoxythiazoles

Abstract

An electrochemical enabled three-component cascaded cyclization of enaminones with potassium thiocyanate and alcohols to access 2-alkoxythiazoles has been developed under external oxidant-free conditions. The reaction proceeded smoothly through the electrochemical oxidation C-H thiolation, nucleophilic tandem cyclization to construct C-O, C-S, and C-N bonds, and the cleavage of the C-N bond. The present protocol afforded a facile and practical approach to various 2-alkoxythiazoles in moderate to good yields from enaminones, thiocyanate and alcohols.