Issue 38, 2023

Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria

Abstract

New valproate Ir(III) and Rh(III) half-sandwich conjugates containing a C,N-phenylbenzimidazole chelated ligand have been synthesized and characterized. The valproic acid conjugation to organometallic fragments seems to switch on the antibacterial activity of the complexes towards Enterococcus faecium and Staphylococcus aureus Gram-positive bacteria.

Graphical abstract: Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria

Supplementary files

Article information

Article type
Communication
Submitted
01 Jun 2023
Accepted
18 Jun 2023
First published
20 Jun 2023
This article is Open Access
Creative Commons BY license

Dalton Trans., 2023,52, 13482-13486

Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria

A. Marco, G. Vigueras, N. Busto, N. Cutillas, D. Bautista and J. Ruiz, Dalton Trans., 2023, 52, 13482 DOI: 10.1039/D3DT01678A

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