Issue 28, 2023

Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity

Abstract

Complexes [{RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2-N,N′-CuCl}2-μ-Cl-μ-OCH3](CF3SO3)2·(CH3OH)4 (1) and [{RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2-N,N′-NiCl}2-μ-Cl-μ-OH](CF3SO3)2 (2) have been synthesized and characterized. Their antiproliferative activities were assessed against six human solid tumours showing nanomolar GI50 values. The effects of 1 and 2 on SW1573 cells colony formation, HeLa cells action mechanism and their interaction with the pBR322 DNA plasmid were evaluated.

Graphical abstract: Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2023
Accepted
29 Jun 2023
First published
29 Jun 2023
This article is Open Access
Creative Commons BY-NC license

Dalton Trans., 2023,52, 9541-9545

Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity

A. Alguacil, F. Scalambra, P. Lorenzo-Luis, A. Puerta, A. González-Bakker, Z. Mendoza, J. M. Padrón and A. Romerosa, Dalton Trans., 2023, 52, 9541 DOI: 10.1039/D3DT01284K

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