Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity

Andrés Alguacil; Franco Scalambra; Pablo Lorenzo-Luis; Adrián Puerta; Aday González-Bakker; Zenaida Mendoza; José M. Padrón; Antonio Romerosa

doi:10.1039/D3DT01284K

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Tetranuclear Ru₂Cu₂ and Ru₂Ni₂ complexes with nanomolar anticancer activity†

Andrés Alguacil,

^a Franco Scalambra,^a Pablo Lorenzo-Luis,

^bc Adrián Puerta,

^b Aday González-Bakker,^b Zenaida Mendoza,^ac José M. Padrón

^b and Antonio Romerosa

*^a

Author affiliations

* Corresponding authors

^a Área de Química Inorgánica-CIESOL, Universidad de Almería, Almería, Spain
E-mail: romerosa@ual.es

^b BioLab, Instituto Universitario de Bio-Orgánica “Antonio Gónzalez”, Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38071 La Laguna, Spain

^c Área de Química Inorgánica, Departamento de Química, Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 3, 38071 La Laguna, Spain

Abstract

Complexes [{RuCp(PPh₃)₂-μ-dmoPTA-1κP:2κ²-N,N′-CuCl}₂-μ-Cl-μ-OCH₃](CF₃SO₃)₂·(CH₃OH)₄ (1) and [{RuCp(PPh₃)₂-μ-dmoPTA-1κP:2κ²-N,N′-NiCl}₂-μ-Cl-μ-OH](CF₃SO₃)₂ (2) have been synthesized and characterized. Their antiproliferative activities were assessed against six human solid tumours showing nanomolar GI₅₀ values. The effects of 1 and 2 on SW1573 cells colony formation, HeLa cells action mechanism and their interaction with the pBR322 DNA plasmid were evaluated.

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Article information

DOI: https://doi.org/10.1039/D3DT01284K
Article type: Communication
Submitted: 28 Apr 2023
Accepted: 29 Jun 2023
First published: 29 Jun 2023
This article is Open Access

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Dalton Trans., 2023,52, 9541-9545

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Tetranuclear Ru₂Cu₂ and Ru₂Ni₂ complexes with nanomolar anticancer activity

A. Alguacil, F. Scalambra, P. Lorenzo-Luis, A. Puerta, A. González-Bakker, Z. Mendoza, J. M. Padrón and A. Romerosa, Dalton Trans., 2023, 52, 9541 DOI: 10.1039/D3DT01284K

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