A zeolitic imidazolate framework-90-based probe for fluorescent detection of mitochondrial hypochlorite in living cells and zebrafish

Ling Zhang; Xi Chen; Wei-Na Wu; Xiao-Lei Zhao; Yun-Chang Fan; Yuan Wang; Zhi-Hong Xu; Ayman Nafady; Abdullah M. Al-Enizi; Shengqian Ma

doi:10.1039/D3DT00829K

A zeolitic imidazolate framework-90-based probe for fluorescent detection of mitochondrial hypochlorite in living cells and zebrafish†

Ling Zhang,‡^a Xi Chen,‡^a Wei-Na Wu,*^a Xiao-Lei Zhao,^a Yun-Chang Fan,^a Yuan Wang,

*^a Zhi-Hong Xu,*^bc Ayman Nafady,^d Abdullah M. Al-Enizi

^d and Shengqian Ma

*^e

Author affiliations

* Corresponding authors

^a College of Chemistry and Chemical Engineering, Henan Key Laboratory of Coal Green Conversion, Henan Polytechnic University, Jiaozuo 454000, P. R. China
E-mail: wuwn08@hpu.edu.cn, wangyuan08@hpu.edu.cn

^b Key Laboratory of Chemo/Biosensing and Detection, College of Chemical and Materials Engineering, Xuchang University, Xuchang, P. R. China
E-mail: xuzhihong1980@xcu.edu.cn

^c College of Chemistry, Zhengzhou University, Zhengzhou, P. R. China

^d Department of Chemistry, College of Science King Saud University, Riyadh, Saudi Arabia

^e Department of Chemistry, University of North Texas, Denton, 76203-5070, USA
E-mail: Shengqian.Ma@unt.edu

Abstract

An inorganic–organic hybrid probe MP-ZIF-90 was synthesized via a simple condensation reaction based on the free CHO groups of zeolitic imidazolate framework-90 (ZIF-90) and 4-methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyridinium bromide (MP). This probe exhibited intense green emission, which was selectively quenched by the addition of ClO⁻ anions. The response of probe MP-ZIF-90 toward ClO⁻ was rapid (within 20 s) and sensitive, with a limit of detection (LOD) of 0.612 μM. Importantly, the utilization of the probe in the fluorescence imaging of ClO⁻ anions in the mitochondria of living cells and zebrafish was demonstrated.

Dalton Transactions

A zeolitic imidazolate framework-90-based probe for fluorescent detection of mitochondrial hypochlorite in living cells and zebrafish†

Abstract

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A zeolitic imidazolate framework-90-based probe for fluorescent detection of mitochondrial hypochlorite in living cells and zebrafish

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