Hierarchical self-assembly in an RNA-based coordination polymer hydrogel

Abstract

An RNA-based coordination polymer is formed by the aqueous reaction of Cu^I ions with the thionucleoside enantiomer (−)6-thioguanosine, (6tGH). The resulting polymer, [Cu^I(μ³-S-thioG)]_n1, has a one-dimensional structure based on a [Cu₄–S₄] core and undergoes extensive hierarchical self-assembly transforming from oligomeric chains → rod → cable → bundle through which a fibrous gel forms, that undergoes syneresis to form a self-supporting mass. The assembly involves the formation of helical cables/bundles and, in combination with the intrinsic photoemission of the polymer, results in the material exhibiting circularly polarised luminescence (CPL).