Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo

Matthew P. Sullivan; Muneebah Adams; Mie Riisom; Caitlin D. Herbert; Kelvin K. H. Tong; Jonathan W. Astin; Stephen M. F. Jamieson; Muhammad Hanif; David C. Goldstone; Christian G. Hartinger

doi:10.1039/D2DT02539F

Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo†

Matthew P. Sullivan,

^ab Muneebah Adams,^a Mie Riisom,

^a Caitlin D. Herbert,^c Kelvin K. H. Tong,^a Jonathan W. Astin,^c Stephen M. F. Jamieson,

^d Muhammad Hanif,

^a David C. Goldstone

^b and Christian G. Hartinger

*^a

Author affiliations

* Corresponding authors

^a School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
E-mail: c.hartinger@auckland.ac.nz

^b School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

^c Department of Molecular Medicine and Pathology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

^d Auckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

Abstract

Pt(terpyridine) complexes are well-known DNA intercalators. The introduction of an NHC co-ligand rendered such a complex highly antiproliferative in cancer cells compared to its chlorido derivative. Despite the high potency, zebrafish embryos tolerated the compound well, especially compared to cisplatin. DNA interaction studies support a mode of action related to intercalation.

Dalton Transactions

Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo†

Abstract

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Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity in vivo

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