Issue 17, 2023

Alkali-metal bases in catalytic hydrogen isotope exchange processes

Abstract

The preparation of compounds labelled with deuterium or tritium has become an essential tool in a range of research fields. Hydrogen isotope exchange (HIE) offers direct access to said compounds, introducing these isotopes in a late stage. Even though the field has rapidly advanced with the use of transition metal catalysis, alkali-metal bases, used as catalysts or under stoichiometric conditions, have also emerged as a viable alternative. In this minireview we describe the latest advances in the use of alkali-metal bases in HIE processes, showcasing their synthetic potential as well as current challenges in the field. It is divided in different sections based on the isotope source used, emphasizing their benefits, disadvantages and limitations. The influence on the choice of alkali-metal in these processes as well as their possible mechanistic pathways are also discussed.

Graphical abstract: Alkali-metal bases in catalytic hydrogen isotope exchange processes

Article information

Article type
Minireview
Submitted
14 Jun 2023
Accepted
14 Jul 2023
First published
18 Jul 2023
This article is Open Access
Creative Commons BY license

Catal. Sci. Technol., 2023,13, 4919-4925

Alkali-metal bases in catalytic hydrogen isotope exchange processes

A. Tortajada and E. Hevia, Catal. Sci. Technol., 2023, 13, 4919 DOI: 10.1039/D3CY00825H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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