Three non-bonding interaction topologies of the thiazole–formaldehyde complex observed by rotational spectroscopy

Abstract

When an aldehyde molecule interacts with a nitrogen atom inserted in an aromatic ring, they form a number of non-bonding topologies. We measured the rotational spectra of three different isomers of the thiazole–formaldehyde adduct. In all of them, formaldehyde interacts specifically with thiazole through an n → π* interaction (along the Bürgi-Dunitz trajectory) and a C–H⋯O (acting as a proton acceptor) weak hydrogen bond, or through C–H⋯N (acting as a proton donor) and C–H⋯O (acting as a proton acceptor) weak hydrogen bonds. The spectra of isotopic substituted species were also measured to draw the molecular structures. Two n → π* stabilized isomers show a vertical structure in which the two molecular planes are perpendicular to each other, and the hydrogen bonded isomers feature a co-planar architecture. The competition between these non-bonding interactions was unveiled from experiments and theoretical calculations.