Issue 100, 2023

Copper-catalyzed atroposelective formal [4+1] annulation of 1,2-diketones with vinyl cations

Abstract

The enantioselective transformation of easily accessible 1,2-diketones represents a quick pathway towards enantioenriched molecules. Herein, we disclose a copper-catalyzed atroposelective formal [4+1] annulation of 1,2-diketones with vinyl cations, enabling the efficient and atom-economical construction of axially chiral arylpyrroles bearing 1,3-dioxole moieties with good to excellent enantioselectivities under mild reaction conditions. Importantly, this methodology constitutes the first enantioselective formal [4+1] annulation of 1,2-diketones.

Graphical abstract: Copper-catalyzed atroposelective formal [4+1] annulation of 1,2-diketones with vinyl cations

Supplementary files

Article information

Article type
Communication
Submitted
28 Sep 2023
Accepted
14 Nov 2023
First published
15 Nov 2023

Chem. Commun., 2023,59, 14831-14834

Copper-catalyzed atroposelective formal [4+1] annulation of 1,2-diketones with vinyl cations

Z. Wang, H. Xu, Y. Chen, L. Ye, B. Zhou and P. Qian, Chem. Commun., 2023, 59, 14831 DOI: 10.1039/D3CC04817A

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