Issue 96, 2023

Solid solution polymorphs afford two highly soluble co-drug forms of tolbutamide and chlorpropamide

Abstract

The search for solid solutions of class-two insulin secretagogues, tolbutamide and chlorpropamide, reveals a rare case of monotropic polymorphism for the mixed crystals. At any stoichiometry, two crystal forms are isolated that are kinetically stable at room temperature from a few months to over a year. Dissolution tests certify the solubility advantage of the solid solutions over the pure drugs as well as their physical mixture, suggesting a potential application as a highly soluble co-drug formulation.

Graphical abstract: Solid solution polymorphs afford two highly soluble co-drug forms of tolbutamide and chlorpropamide

Supplementary files

Article information

Article type
Communication
Submitted
22 Sep 2023
Accepted
10 Nov 2023
First published
10 Nov 2023

Chem. Commun., 2023,59, 14321-14324

Solid solution polymorphs afford two highly soluble co-drug forms of tolbutamide and chlorpropamide

E. Spoletti, V. Verma, C. Cappuccino and M. Lusi, Chem. Commun., 2023, 59, 14321 DOI: 10.1039/D3CC04725C

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