Issue 97, 2023

Development of 18F-Labeled hydrophilic trans-cyclooctene as a bioorthogonal tool for PET probe construction

Abstract

We report the development of a hydrophilic 18F-labeled a-TCO derivative [18F]3 (log P = 0.28) through a readily available precursor and a single-step radiofluorination reaction (RCY up to 52%). We demonstrated that [18F]3 can be used to construct not only multiple small molecule/peptide-based PET agents, but protein/diabody-based imaging probes in parallel.

Graphical abstract: Development of 18F-Labeled hydrophilic trans-cyclooctene as a bioorthogonal tool for PET probe construction

Supplementary files

Article information

Article type
Communication
Submitted
30 Aug 2023
Accepted
12 Oct 2023
First published
17 Oct 2023

Chem. Commun., 2023,59, 14387-14390

Development of 18F-Labeled hydrophilic trans-cyclooctene as a bioorthogonal tool for PET probe construction

M. Xu, X. Ma, J. E. Pigga, H. Zhang, S. Wang, W. Zhao, H. Deng, A. M. Wu, R. Liu, Z. Wu, J. M. Fox and Z. Li, Chem. Commun., 2023, 59, 14387 DOI: 10.1039/D3CC04212J

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