Issue 85, 2023

N-Heterocyclic imino-catalyzed 1,4-regioselective azide–alkyne cycloaddition (AAC): a metal-free approach

Abstract

An unprecedented synthetic approach has been devised to efficiently synthesize regioselective 1,4-disubstituted 1,2,3-triazoles. This technique relies on the use of innovative metal-free highly basic N-heterocyclic imino catalysts. The experimental observations have been supported further by TD-DFT computational studies.

Graphical abstract: N-Heterocyclic imino-catalyzed 1,4-regioselective azide–alkyne cycloaddition (AAC): a metal-free approach

Supplementary files

Article information

Article type
Communication
Submitted
22 Aug 2023
Accepted
19 Sep 2023
First published
20 Sep 2023

Chem. Commun., 2023,59, 12699-12702

N-Heterocyclic imino-catalyzed 1,4-regioselective azide–alkyne cycloaddition (AAC): a metal-free approach

S. Revathi, A. L. Shinde, M. K. Rajashekhar, D. Mandal, A. R. Maity, S. Garai and T. Ghatak, Chem. Commun., 2023, 59, 12699 DOI: 10.1039/D3CC04065H

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