Issue 71, 2023

Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Abstract

Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure–activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.

Graphical abstract: Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

Supplementary files

Article information

Article type
Communication
Submitted
12 Jul 2023
Accepted
04 Aug 2023
First published
04 Aug 2023

Chem. Commun., 2023,59, 10660-10663

Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity

A. Chan, P. Shan, M. Wu, P. Lin, C. Tsai, C. Hsu, T. Chiu, T. Hsu, Y. Yeh, Y. Lai, W. Liu and L. Tu, Chem. Commun., 2023, 59, 10660 DOI: 10.1039/D3CC03363E

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