Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity†
Abstract
Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure–activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.