Issue 74, 2023

Benchtop nickel-catalyzed reductive coupling of aldehydes with alkynes and ynamides

Abstract

We demonstrate the potential of Ni(COD)(DQ), a bench-stable Ni0 complex, as a catalyst for the reductive coupling of aldehydes with alkynes and ynamides, providing silylated allyl alcohols with excellent yields and regioselectivities. Mass spectrometric identification of the intermediates and DFT studies supported the proposed mechanism.

Graphical abstract: Benchtop nickel-catalyzed reductive coupling of aldehydes with alkynes and ynamides

Supplementary files

Article information

Article type
Communication
Submitted
10 Jul 2023
Accepted
23 Aug 2023
First published
24 Aug 2023

Chem. Commun., 2023,59, 11141-11144

Benchtop nickel-catalyzed reductive coupling of aldehydes with alkynes and ynamides

A. Khamrai and V. Ganesh, Chem. Commun., 2023, 59, 11141 DOI: 10.1039/D3CC03322H

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