Issue 70, 2023
From the journal:

Chemical Communications

Effective assessment of lanthanide ion delivery into live cells by paramagnetic NMR spectroscopy†

Jia-Liang Chen, ORCID logo *ab   Yin Yang,b   Tiesheng Shi ORCID logo a  and  Xun-Cheng Su ORCID logo *b  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Zaozhuang University, Zaozhuang, Shandong, China
E-mail: 819093@nankai.edu.cn

b State Key Laboratory of Elemento-organic Chemistry, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin 300071, China
E-mail: xunchengsu@nankai.edu.cn

Abstract

We report an effective assessment of lanthanide ion (Ln3+) delivery into live cells by paramagnetic NMR spectroscopy. Free Ln3+ ions are toxic to live cells resulting in a gradual leakage of target proteins to the extracellular media. The citrate–Ln3+ complex is an efficient and mild reagent over the free Ln3+ form for live cell delivery.

Graphical abstract: Effective assessment of lanthanide ion delivery into live cells by paramagnetic NMR spectroscopy

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D3CC03135G
Article type
Communication
Submitted
29 Jun 2023
Accepted
07 Aug 2023
First published
07 Aug 2023

Chem. Commun., 2023,59, 10552-10555

Permissions

Request permissions

Effective assessment of lanthanide ion delivery into live cells by paramagnetic NMR spectroscopy

J. Chen, Y. Yang, T. Shi and X. Su, Chem. Commun., 2023, 59, 10552 DOI: 10.1039/D3CC03135G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements