Issue 74, 2023

Gallium reactivates first and second generation quinolone antibiotics towards drug-resistant Klebsiella pneumoniae

Abstract

Herein, we report on a series of homoleptic [GaL3] and heteroleptic organometallic [GaMe2L] complexes of inactive quinolone antibiotics; nalidixic acid, oxolinic acid and norfloxacin with their antibacterial activity (MIC 0.024–0.781 μM) towards four multi-drug resistant strains of Klebsiella pneumoniae through complexation to gallium.

Graphical abstract: Gallium reactivates first and second generation quinolone antibiotics towards drug-resistant Klebsiella pneumoniae

Supplementary files

Article information

Article type
Communication
Submitted
22 Jun 2023
Accepted
21 Aug 2023
First published
23 Aug 2023

Chem. Commun., 2023,59, 11093-11096

Gallium reactivates first and second generation quinolone antibiotics towards drug-resistant Klebsiella pneumoniae

T. Sultana, R. N. Duffin, V. L. Blair and P. C. Andrews, Chem. Commun., 2023, 59, 11093 DOI: 10.1039/D3CC02916F

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