Issue 66, 2023

Imidazolium-based mass tags for protein biomarker detection using laser desorption ionization mass spectrometry

Abstract

Novel imidazolium-based mass tags (IMTs) were designed, synthesized and applied to simultaneous in situ analysis of multiple biomarkers on less than 10 cells. The high sensitivity, flexible extensibility and excellent distinguishability of IMTs open new avenues for designing common mass tag templates suitable for mass spectrometric immunoassay and provide an ideal option for multiplex-sensitive detection at the cellular scale.

Graphical abstract: Imidazolium-based mass tags for protein biomarker detection using laser desorption ionization mass spectrometry

Supplementary files

Article information

Article type
Communication
Submitted
16 Jun 2023
Accepted
17 Jul 2023
First published
22 Jul 2023

Chem. Commun., 2023,59, 9996-9999

Imidazolium-based mass tags for protein biomarker detection using laser desorption ionization mass spectrometry

M. Liu, J. Xue, H. Liu and Y. Bai, Chem. Commun., 2023, 59, 9996 DOI: 10.1039/D3CC02907G

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