Issue 77, 2023

Catalytic cascade synthesis of cyanohydrin esters via water/O2-induced cyanide transfer from K3Fe(CN)6

Abstract

The copper-catalyzed α-oxygenation of aryl benzyl ketones is merged with a unique water/O2-induced release of cyanide ions from K3Fe(CN)6 and a benzil-cyanide reaction. This strategy gives expedient access to cyanohydrin esters starting directly from broadly accessible aryl benzyl ketones. The cyanide release strategy was further integrated with a copper catalyzed oxygenation-decarbonylation sequence to produce cyanohydrin esters from 1,3-diketones.

Graphical abstract: Catalytic cascade synthesis of cyanohydrin esters via water/O2-induced cyanide transfer from K3Fe(CN)6

Supplementary files

Article information

Article type
Communication
Submitted
07 Jun 2023
Accepted
26 Aug 2023
First published
28 Aug 2023

Chem. Commun., 2023,59, 11544-11547

Catalytic cascade synthesis of cyanohydrin esters via water/O2-induced cyanide transfer from K3Fe(CN)6

A. K. Singh, S. S. Chauhan and S. Bhadra, Chem. Commun., 2023, 59, 11544 DOI: 10.1039/D3CC02743K

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