Issue 61, 2023

An efficient Selectfluor-mediated condensation of indoles and anthranilates for the synthesis of indoloquinazolinones

Abstract

Intermolecular fluorocyclization of indoles with anthranilates, which proceeded smoothly to give diverse indoloquinazolinone architectures under mild reaction conditions, has been developed. A wide range of substrates were compatible with this cyclization system. The synthetic fluorinated compounds could be modified by their conversion to various substituted quinazolinones for drug discovery. In addition, this protocol has been applied to the concise total synthesis of bioactive natural alkaloids phaitanthrins A–B, cephalanthrin A and cruciferane.

Graphical abstract: An efficient Selectfluor-mediated condensation of indoles and anthranilates for the synthesis of indoloquinazolinones

Supplementary files

Article information

Article type
Communication
Submitted
03 Jun 2023
Accepted
30 Jun 2023
First published
30 Jun 2023

Chem. Commun., 2023,59, 9368-9371

An efficient Selectfluor-mediated condensation of indoles and anthranilates for the synthesis of indoloquinazolinones

X. Wang, Z. Wu, G. Tu, Y. Zhao and X. Xiong, Chem. Commun., 2023, 59, 9368 DOI: 10.1039/D3CC02673F

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