Issue 62, 2023

DNA-compatible combinatorial synthesis of functionalized 2-thiobenzazole scaffolds

Abstract

2-Thiobenzazole is among the privileged heterocyclic scaffolds in medicinal chemistry. Constructing such structural components in DNA-encoded libraries (DELs) may promote related bioactive hit discovery in a high-throughput fashion. Herein, we reported a DNA-compatible mild-condition synthetic methodology to efficiently forge functionalized 2-thiobenzazole scaffolds, realizing on-DNA sulfhydryl incorporation with broad substrate scope, thereby expanding the scope of 2-thiobenzazole-focused DNA-encoded chemical libraries.

Graphical abstract: DNA-compatible combinatorial synthesis of functionalized 2-thiobenzazole scaffolds

Supplementary files

Article information

Article type
Communication
Submitted
30 May 2023
Accepted
05 Jul 2023
First published
05 Jul 2023

Chem. Commun., 2023,59, 9489-9492

DNA-compatible combinatorial synthesis of functionalized 2-thiobenzazole scaffolds

X. Li, C. Liu, Y. Gao, G. Zhang, Y. Li and Y. Li, Chem. Commun., 2023, 59, 9489 DOI: 10.1039/D3CC02593D

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