Integrin-mediated cellular delivery was attempted to optimize practical applications of hydrophobic ionophores. The potent ionophore preferentially transports H+/Cl− across the lipid bilayers following a symport mechanism. The RGD-peptide-appended tag was stimulated by glutathione to generate the active ionophore, prompting the transport of Cl− under the cellular environment.
S. Srimayee, S. R. Badajena, N. Akhtar, M. K. Kar, S. Dey, P. Mohapatra and D. Manna, Chem. Commun., 2023, 59, 12759 DOI: 10.1039/D3CC02451B
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